The Genomic Revolution

Technological innovations in the mid 1970's led to methods of isolating specific regions of DNA from complex genomes and determining their chemical structure (see Glossary for definition of terms). This culminated in the determination of the complete DNA sequence of the human genome, which was formally announced in April, 2003. The code of the human genome consists of over 3 billion "letters" (called bases; either A, T, G or C) of DNA, and the entire sequence is now known. The human genome includes approximately 20,000 different genes that encode proteins. Although the genomes of all humans are almost identical, there are minor DNA sequence variations in each individual (between 1% and 3% of the total DNA) that makes their genome unique. These DNA sequence variations give each of us our unique personal characteristics.

The new tools of molecular biology and molecular genetics have also greatly advanced the medical sciences. Increased knowledge of biological systems has led to a much deeper understanding of both human health and disease. This has led to the discovery and development of targeted therapeutics that are more specific than traditional pharmaceutical drugs. There are several such therapeutics that have already received FDA approval, and many more will become available in years to come. It is estimated that nearly half of the new medications in development are targeted drugs. The majority of these will be prescribed to individuals based on their own genetics. These and future developments will revolutionize human health care. In addition to improving medical care, the new era of genomics can allow each individual to lead a healthier life based on their personal genetics. Such proactive use of genomic information can decrease the necessity of future medical interventions. Individuals can also utilize genomic information to improve many other aspects of their lives.

At Genomic Express, we believe that your genetic information is your personal property. You are entitled to confidentially obtain and maintain control of your genetic information. There are numerous ways knowledge of your own genetics can benefit you. We formed Genomic Express to bring the power of personalized genomics directy to individuals. We want to empower you to take advantage of your unique genome to live a healthier, more productive life. The mission of Genomic Express is to help you obtain, understand and maximize the value of your genomic information.